Home  >  Products  >  CD28 (CD28 Antigen, CD28 Molecule, MGC138290, T cell Antigen CD28, T cell Specific Surface Glycoprotein, T cell Specific Surface Glycoprotein CD28, Tp44)
CD28 (CD28 Antigen, CD28 Molecule, MGC138290, T cell Antigen CD28, T cell Specific Surface Glycoprotein, T cell Specific Surface Glycoprotein CD28, Tp44)

CD28 (CD28 Antigen, CD28 Molecule, MGC138290, T cell Antigen CD28, T cell Specific Surface Glycoprotein, T cell Specific Surface Glycoprotein CD28, Tp44)

Cat no: C2380-01J1

Supplier: United States Biological
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CD28 is a t ype of I disulfide-linked homodimer that is expressed on most thymocytes and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells and plays an important role in the interaction between T cells and B cells. CD28 is a co-stimulatory receptor involved in many but not all T cell independent immune responses. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:25-1:50; 10ul labels 10e6 cells or 100ul whole blood. Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Hybridoma: Y3/Ag 1.2.3 rat myeloma cells with spleen cells from DA rat. Recommended Secondary Antibodies: I1903-14Y: IgG, H&L (FITC) I1904-47R: IgG, H&L (FITC) Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2380-01J1
Reactivities: Human
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Reiter, C. (1989) Cluster Report: CD28 in Leucocyte Typing IV: White Cell Differentiation Antigens. Edited by Knapp, W., Dorken, B., Gilks, W.R., Rieber, E.P., Schmidt, R.E., Stein, H. and von dem Borne, A.E.G.Kr. Oxford University Press. pp 352-353, 2. Galea-Lauri, J. et al. (1999) J. Immunol. 163: 62-70. 3. Gabdoulkhakova, A. et al. (2007) Immunogenetics. 59: 135-43.4. Pridgeon, C. et al. (2011) Clin Sci (Lond). 120: 515-24. 5. Blanco, B. et al. (2003) J Immunol. 171: 1070-7. 6. Costa, C. et al. (2002) J Immunol. 168: 3808-16.
Additional info: Recognizes human CD28.

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