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CD28 (T-cell-specific Surface Glycoprotein CD28, TP44)

CD28 (T-cell-specific Surface Glycoprotein CD28, TP44)

Cat no: C2380-08N

Supplier: United States Biological
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CD28, a 44kD homodimer and T-cell membrane glycoprotein, is a member of the Ig super family. It binds B7 molecules on APCs and transmits vital co-stimulatory signals required for proper T-cell proliferation, survival, IL-2 production and Th2 development. CD28 plays a vital role in recruitment of signaling molecules to the TCR including PI3K, PKB/Akt, Src Kinase Lck, Tec Kinases, PTKs, Vav-1, IKKalpha, Grb2, SLP76, p21ras and PAK. CD28/B7 interactions activate various signaling pathways including PI3K/Akt signaling, PTK-signaling, NF-kappaB activation and Rho-GTPase signaling. CD28 co-stimulation and ligation with TCR/CD3 complex directly controls T-cell cycle progression by down-regulating CDK inhibitor p27Kip1. These interactions also up-regulate Bcl-XL expression and down-regulate FasL expression thus playing a vital role in T-cell survival. Blocking of CD28/B7 pathway results in immunosuppression with implications for treatment of autoimmune diseases, organ transplantation and graft vs. host disease. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2380-08N
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Hutloff, A. et. al. Nature (1999) 397: 263-266 2. Greenfield et.al Crit Rev Immunol., 18(5):389-418 (1998) 3. Y Colette et.al Blood, 92 (4) 1350-1363 (Aug' 15 1998) 4. Piccollela et.al The Journal of Immunology 170: 2895-2903 (2003) 5. Fontana et.al The Journal of Immunology 171: 2225-2232 (2003) 6. Andres et.al Nat Immunol., 5(4):435-42 (2004 Apr) 7. Riley et.al Blood 105(1): 13
Additional info: Recognizes human CD28.

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