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CD28 (T-cell-specific Surface Glycoprotein CD28, TP44)

CD28 (T-cell-specific Surface Glycoprotein CD28, TP44)

Cat no: C2380-16L

Supplier: United States Biological
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CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subset, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered as a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2380-16L
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 2. Nunes, J., et al. 1993. Biochem. J. 293:835. 3. Calea-Lauri, J., et al. 1999. J. Immunol. 163:62. 4. Tazi, A., et al. 1999. J. Immunol. 163:3511. (IHC) 5. Marti, F., et al. 2001. J. Immunol. 166:197. (Costim) 6. Jeong, S.H., et al. 2004. J. Virol. 78:6995. (Costim) 7. Rivollier, A., et al. 2004. Blood 104:4029. (Costim) 8. Scharschmidt, E., et al. 2004. Mol. Cell Biol. 24:3860. (Costim) 9. Sheng, W., et al. 2007.Elsevier 580:6819. 10. Mitsuhashi, M., 2007. Clin Chem. 53:148. 11. Ye, Z., et al. 2008. Infect. Immun. 76:2541. 12. Magatti, M., et al. 2008. Stem Cells 26:182. (FA) 13. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 14. Rout, N., et al. 2010. PLoS One 5:e9787. (FC) 15. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 16. June, C.H., et al. 1994. Immunol. Today. 15: 321. 17. Linskey, P.S., et al. 1993. Annu. Rev. Immunol. 11:191. 4.
Additional info: Recognizes human CD28. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus.

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