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CD29 (Integrin beta-1, Fibronectin Receptor Subunit beta, VLA-4 Subunit beta, ITGB1, FNRB, MDF2, MSK12)

CD29 (Integrin beta-1, Fibronectin Receptor Subunit beta, VLA-4 Subunit beta, ITGB1, FNRB, MDF2, MSK12)

Cat no: C2381-03K

Supplier: United States Biological
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CD29 is a 130 kD single chain type I glycoprotein, known as integrin b1, VLA-b chain, or gpIIa. It is broadly expressed on a majority of hematopoietic and non-hematopoietic cells, including leukocytes (although at low level on granulocytes), platelets, fibroblasts, endothelial cells, epithelial cells, and mast cells. CD29 is a member of the integrin family. It is non-covalently associated with integrin a1-a6 chains to form VLA-1 to VLA-6 molecules, respectively. Integrins which include CD29 bind to several cell surface (e.g. VCAM-1, MadCAM-1) and extracellular matrix molecules. CD29 acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2381-03K
Reactivities: Human, Bovine
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 2. Gutierrez-Lopez, M., et al. 2003. J. Biol. Chem. 278:208. 3. Hemler, M.E., et al. 1984. J. Immunol. 132:3011. 4. Sanchez-Aparicio, P., et al. 1994. J. Cell Biol. 126:271. 5. Frank, N.Y., et al. 2005. Cancer Res. 65:4320. 6. Murga, M., et al. 2005. Blood 105:1992. 7. Porter, J.C. and Hogg, N., 1997. J. Cell Biol. 138:1437. 8. Conway, R. E., et al. 2006. Mol. Cell. Biol. 26:5310. 9. Hemler, M. 1990. Annu. Rev. Immunol. 8:365. 10. Hynes, R. 1992. Cell 69:11.
Additional info: Recognizes human CD29. Species Crossreactivity: bovine.

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