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CD29 (Integrin beta 1) (FITC)

CD29 (Integrin beta 1) (FITC)

Cat no: C2381-10W

Supplier: United States Biological
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Integrin beta 1, also known as CD29, is a 130kD transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow cytometry: 2ug/ml. 20ul reagent/100ul whole blood Immunoprecipitation: 1:50 Western Blot: 2ug/ml non-reducing conditions recommended. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
Catalogue number: C2381-10W
Reactivities: Human, Canine, Porcine
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Size: 100 tests
Form: Supplied as a liquid in PBS, pH 7.4, BSA, 15mM sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG1
Purity: Purified
Alternative names: beta 1 subunit, CD29 antigen, Fibrinogen Receptor beta subunit, GPIIA, ITGB1, MDF2, Very Late Activation Protein beta Polypeptide, VLAB, VLAbeta
References: 1. Leukocyte Typing VI. Kishimoto, T., et al. (Eds.), Garland Publishing Inc. (1997). 2. Simova S, Klima M, Cermak L, Sourkova V, Andera L. : Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis;13(3):423-36. 2008 Mar. [PMID: 18165900]
Additional info: Recognizes human Integrin beta 1. Species Crossreactivity: canine and porcine. Does not react with mouse.

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