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CD3 (CD3d, CD3e, CD3g, CD3z, Early T Cell Marker, T Cell Receptor Complex, TCR, T-cell Surface Glycoprotein CD3)

CD3 (CD3d, CD3e, CD3g, CD3z, Early T Cell Marker, T Cell Receptor Complex, TCR, T-cell Surface Glycoprotein CD3)

Cat no: C2254-56E

Supplier: United States Biological
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T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Applications: Suitable for use in Immunofluorescence, Immunohistochemistry and Cytotoxic Assay. Other applications not tested. Recommended Dilution: Immunohistochemistry (Frozen): 1:10-1:20 Not suitable for paraffin embedded tissue. Dilute in PBS. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2254-56E
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in PBS, 0.1% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Ascites
Alternative names: CD247, T-cell Surface Glycoprotein CD3 delta Chain, T-cell Receptor T3 delta Chain, T3D, T-cell Surface Glycoprotein CD3 gamma Chain, T-cell Receptor T3 gamma Chain, T3G, T-cell Surface Glycoprotein CD3 epsilon Chain, T-cell Surface Antigen T3/Leu-4 epsilon Chain, T3E, T-cell Surface Glycoprotein CD3 zeta Chain, T-cell Receptor T3 zeta Chain, T3Z, TCRZ
References: 1. Spits, H., et al., 1983, Hybridoma 4, 423. 2. de Vries J.E., and H. Spits, 1984 J. Immunology 132, 510. 3. Yssel H., H. Spits and J.E. de Vries, 1984, J. Exp. Med. 160, 239. 4. Geisler C., et al., 1988, Scand. J. Immunol. 28, 741.
Additional info: Recognizes human CD3, 19-29 kD, present on all resting and activated human T-cells, on T-leukemia cells and a proportion of human thymocytes.

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