Home  >  Products  >  CD301 (CD301 Antigen, C-type Lectin Domain Family 10 Member A, CLEC10A, CLECSF13, C-type Lectin Superfamily Member 14, CLECSF14, HML2, Macrophage Lectin 2)
CD301 (CD301 Antigen, C-type Lectin Domain Family 10 Member A, CLEC10A, CLECSF13, C-type Lectin Superfamily Member 14, CLECSF14, HML2, Macrophage Lectin 2)

CD301 (CD301 Antigen, C-type Lectin Domain Family 10 Member A, CLEC10A, CLECSF13, C-type Lectin Superfamily Member 14, CLECSF14, HML2, Macrophage Lectin 2)

Cat no: C2549-29A

Supplier: United States Biological
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CD301 is a 38kD cell surface protein that is otherwise known as macrophage galactose N-acetylgalactosamine lectin (MGL) or dendritic cell asialoglycoprotein (DC-ASGPR). In mice, CD301 is predominantly expressed on mature macrophages found associated with a wide range of connective tissues including macrophages in the dermis and the pancreas. Expression of CD301 is induced by alternative (i.e. IL-4/IL-13 mediated) activation of macrophages and dendritic cells, but not all CD301 positive cells are necessarily IL-4/IL-13 stimulated. Applications: Suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:100-1:200; 10ul labels 10e6 cells in 100ul Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Hybridoma: Rat Y3-Ag1.2.3 myeloma cells fused with cells from immunized rats. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2549-29A
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 250ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Leenen, P.J.M. et. al. (1994) J Immunol Methods. 174: 5-19. 2. Geutskens, S.B. et. al. (2005) J Leukoc Biol. 78: 845-852. 3. Abadie, V. et al. (2005) Blood. 106: 1843-50. 4. Dupasquier, M. et al. (2004) J Invest Dermatol. 123: 876-9. 5. Sindrilaru, A. et al. (2011) A J Clin Invest. 121: 985-97. 6. Westcott, D.J. et al. (2009) J Exp Med. 206: 3143-56. 7. Fischer-Posovszky, P. et al. (2011) Endocrinology. 152: 3074-81. 8. Spite, M. et al. (2011) J Immunol. 187: 1942-9. 9. Raes, G. et al. (2005) J Leukoc Biol. 77: 321-7. 10. Freire, T. et al. (2010) Blood. 116: 3526-36. 11. Lumeng, C.N. et al. (2008) Diabetes. 57: 3239-46. 12. Blyszczuk, P. et al. (2012) Cardiovasc Res. Nov 7. 13. Sindrilaru, A. et al. (2011) J Clin Invest. 121: 985-97. 14. Ferret-Bernard, S. et al. (2012) J. Proteomics. 75: 938-48. 15. Orr, J.S. et al. (2012) Diabetes. 61: 2718-27.
Additional info: Recognizes mouse CD301, a 38kD cell surface protein. Also detects a population of dendritic cells in lymphoid tissue, which are probably recent immigrants from peripheral connective tissue sites. Reported to block the function of mouse CD301. Binds both MGL1 and MGL2 homologs.

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