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CD31 (CD31 Antigen, EndoCAM, FLJ58394, GPIIA, Platelet Endothelial Cell Adhesion Molecule, PECA1, Pecam 1, Pecam1, Pecam-1)

CD31 (CD31 Antigen, EndoCAM, FLJ58394, GPIIA, Platelet Endothelial Cell Adhesion Molecule, PECA1, Pecam 1, Pecam1, Pecam-1)

Cat no: C2383-03K

Supplier: United States Biological
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CD31 (PECAM-1, Platelet gpIIa Molecule), a ~130kD integral membrane glycoprotein, is expressed in platelets, cultured endothelial cells, monocytes, normal tissue macrophages in tonsil, lung and kidney, skin biopsies from conditions such as sarcoidosis and lepromatous leprosy and bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 mediates cell-cell adhesion. Valuable iin the study of benign and malignanat vaascular tumors. Stainiing for CD31 has also been used to measure angiogenesis, which reportedly predicts tumor recurrence. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Functional studies on cell-cell interactions, and Studies on integrity of endothelial cell monolayers. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2383-03K
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence
Size: 1ml
Form: Supplied as a liquid in 10mg BSA, 0.1% sodium azide, 20mM TRIS, 150mM NaCl, pH 8.0.
P type: Mab
Isotype: IgG1
Purity: Purified by immunoaffinity chromatography.
Alternative names: Platelet/endothelial Cell Adhesion Molecule
References: 1. Mourik, J.A., et al., 1985, J. Biol. Chem. 260, 11300. 2. Newman, P.J., et al., 1990, Science 247, 1219.
Additional info: Recognizes human CD31. Also reacts with platelets, monocytes, granulocytes, subset of T cells, NK cells and B-cells. In immunohistology reacts with endothelial cells, weakly with histocytes and glomeruli.

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