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CD31 (CD31 Antigen, EndoCAM, GPIIA, Platelet Endothelial Cell Adhesion Molecule, Pecam 1, Pecam1, Pecam-1)

CD31 (CD31 Antigen, EndoCAM, GPIIA, Platelet Endothelial Cell Adhesion Molecule, Pecam 1, Pecam1, Pecam-1)

Cat no: C2383-03E

Supplier: United States Biological
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CD31 (PECAM-1, Platelet gpIIa Molecule), a ~130kD integral membrane glycoprotein, is expressed in platelets, cultured endothelial cells, monocytes, normal tissue macrophages in tonsil, lung and kidney, skin biopsies from conditions such as sarcoidosis and lepromatous leprosy and bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 mediates cell-cell adhesion. Valuable iin the study of benign and malignanat vaascular tumors. Stainiing for CD31 has also been used to measure angiogenesis, which reportedly predicts tumor recurrence. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry, Immunofluorescence and Immunoprecipitation. Not suitable for Western Blot. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10-1:50; 10ul labels 10e6 cells or 100ul whole blood. Immunohistochemistry: frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2383-03E
Reactivities: Human, Porcine
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Size: 2ml
Form: Supplied as a liquid, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Evans, P.C. et al. (2001) Signaling through CD31 protects endothelial cells from apoptosis. Transplantation. 71 (3): 343 - 4. 2. Gesslein, B. et al. (2010) Mol Vis. 16: 392-407 3. Gyongyosi, M. et al. (2010) Thromb Haemost. 103: 1-9 .4. Iohara, K. et al. (2008)Stem Cells. 26: 2408-2418. 5. Campos, E. et al. (2004)Vet Res. 35: 625-33. 6. Graham, J.J. et al. (2010) Am J Physiol Heart Circ Physiol. 299: H125-33. 7. Gyongyosi, M. et al. (2010) Thromb Haemost. 2010 Aug;104(2):376-84. 8. Katchman, H. et al. (2008) Stem Cells. 26: 1347-55. 9. Poirier, N. et al. (2010)Sci Transl Med. 2: 17ra10. 10. Tchorsh-Yutsis, D. et al. (2009)Diabetes. 58: 1585-94. 11. Waksman, R. et al. (2006) Heart. 92: 1138-44. 12. Chatelais, M. et al. (2011) Xenotransplantation. 18: 108-20. 14. Chitalia, V.C. et al. (2011) Nephrol Dial Transplant. 26: 3858-65.
Additional info: Recognizes porcine CD31, a 140kD cell surface protein also called PECAM-1. Has been shown to stimulate tyrosine phosphorylation of CD31 on endothelial cells. CD31 is expressed by various cell types, but particularly by endothelial cells. Species crossreactivity: human.

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