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CD31 (PECAM-1, Platelet gpIIa Molecule)

CD31 (PECAM-1, Platelet gpIIa Molecule)

Cat no: C2383-02F

Supplier: United States Biological
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Platelet endothelial cell adhesion molecule-1 (CD31/PECAM-1) is a cell-cell adhesion molecule that is expressed on circulating platelets, on leukocytes, and at the intercellular junctions of vascular endothelial cells, where it mediates the interactions of these cells during the process of transendothelial cell migration, thrombosis, wound healing, and angiogenesis (1, 2). CD31/PECAM-1 is an important target glycoprotein in drug-induced immune thrombocytopenia (DITP), a serious complication of drug treatment (3). CD31/PECAM-1 is the physiological ligand for CD38, where expression in a high percentage of malignant cells is a risk factor for patients with B-cell chronic lymphocytic leukemia (B-CLL) (4). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:5,000-1:20,000 Immunohistochemistry: 1:250-1:500 Flow cytometry: 1:70 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2383-02F
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: PECAM-1, EndoCAM, GPIIA', CD31 antigen
References: 1. Albelda SM, et al. J Cell Biol. 114(5):1059-68, 1991 2. Kirschbaum NE, et al. Blood. 84(12):4028-37, 1994 3. Kroll H, et al. Blood. 96(4):1409-14, 2000 4. Mainou-Fowler T, et al. Int J Oncol. 33(1):169-74, 2008
Additional info: Recognizes human CD31/PECAM-1.

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