CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1) is a type I integral membrane glycoprotein, and a member of the immunoglobulin superfamily of cell surface receptors. PECAM-1 is constitutively expressed on the surface of endothelial cells where it is concentrated at cell junctions. PECAM-1 is also expressed at low levels on all leukocytes and platelets. Homotypic interaction of CD31 is important in cell-cell interaction, cell-matrix interaction and signal transduction.
Applications:
Suitable for use in Flow Cytometry, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 1:70
Western Blot: 1:5,000-20,000
Immunohistochemistry (paraffin): 1:250-500
Optimal dilutions to be determined by the researcher.
Positive Control:
THP-1 and Jurkat cell lysates
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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