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CD31 (PECAM-1, Platelet gpIIa Molecule, Endothelial Cell Marker)

Cat no: C2383-04N


Supplier: United States Biological
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CD31, a 130kD transmembrane glycoprotein, is a member of Ig superfamily. It is expressed in platelets, monocytes, granulocytes, B cells, certain T-cell subsets and endothelial cells. It exists as a heavily-glycosylated dimer and is a major constituent of endothelial cell intercellular junction. It consists of 6 extracellular Ig-like domains, a transmembrane domain and an ITIM domain within its cytoplasmic domain. Its physiological functions include cell adhesion, transendothelial migration of leukocytes, regulating B-cell activation, vasculogenesis, angiogenesis and integrin activation. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:10-1:25 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2383-04N
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Parums et al. J Clin Pathol 43: 752, 1990. 2. Tang et al. JBC 268 (30): 22883 (1993) 3. Luu et.al J Vasc Res. 40(5):467-79 (2003 Sep-Oct) 4. Tang et al. JBC 268 (30): 22883 (1993) 5. Luu et.al J Vasc Res. 40(5):467-79 (2003 Sep-Oct).
Additional info: Recognizes human CD31.

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