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CD31 (PECAM-1, Platelet gpIIa Molecule) (FITC)

CD31 (PECAM-1, Platelet gpIIa Molecule) (FITC)

Cat no: C2383-02G

Supplier: United States Biological
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CD31 is a member of the immunoglobulin superfamily. This heavily glycosylated protein is found in the entire vascular endothelium of adult mice and functions in mediating cellular adhesion by heterophilic and homophilic mechanisms. CD31 is detected within the lymphopoietic islands in the spleen of newborn (day 12) and in the bone marrow of adult mice. Capillary endothelial cells of adult mice also express CD31. The reactivity of the monoclonal antibody is restricted to the isoform of the molecule that is selectively expressed by endothelial cells. The antibody precipitates a 130kD molecule present on the membrane of endothelial cell presents on all mouse blood vessels both in normal, inflamed or tumor tissues. The antigen is predominantly present at the lateral borders of endothelial cells as described for human CD31. Applications: Suitable for use in Flow Cytometry, Immunoassay, and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Catalogue number: C2383-02G
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide, 1% BSA. Labeled with fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: CD31, Endocam, GP!!A
References: 1. Vecchi, A et al; Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur J Cell Biol 1994, 63: 247 2. Dong, Q et al; A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants. Arterioscler Thromb Vasc Bio 1997, 17: 1599 3. Xu, Q et al; Circulating progenitor cells regenerate endothelium of vein graft atherosclerosis, which is diminished in ApoE-deficient mice. Circ Res 2003, 93: e76
Additional info: Recognizes mouse Platelet-Endothelial Cell Adhesion Molecule (PECAM)-1 (CD31).

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