Home  >  Products  >  CD32 (Low Affinity Immunoglobulin gamma Fc Region Receptor II-b, IgG Fc Receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, FCGR2B, FCG2, IGFR2)
CD32 (Low Affinity Immunoglobulin gamma Fc Region Receptor II-b, IgG Fc Receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, FCGR2B, FCG2, IGFR2)

CD32 (Low Affinity Immunoglobulin gamma Fc Region Receptor II-b, IgG Fc Receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, FCGR2B, FCG2, IGFR2)

Cat no: C2384-10D

Supplier: United States Biological
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CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcgRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform). Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2384-10D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Kishimoto, T., et al. 1997. Leucocyte Typing VI, Garland Press. London. 2. Lerino, F., et al. 1993. J. Immunol. 150:1794. 3. van Tits, L., et al. 2005. Arterioscler Thromb Vasc Biol. 25: 717. 4. Smeltz, R. B., 2007. J. Immunol. 178:4786. 5. Stuart, S., et al. 1989. EMBO J. 8:3657. 6. Huang, Y., et al. 1999. Scand. J. Immunol. 49:177. 7. Hisaka, H., et al. 1999. Pathobiology 67:92.
Additional info: Recognizes human CD32.

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