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CD35 (Complement Receptor Type 1, C3b/C4b Receptor, CR1, C3BR)

CD35 (Complement Receptor Type 1, C3b/C4b Receptor, CR1, C3BR)

Cat no: C2387-10E

Supplier: United States Biological
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CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, follicular dendritic cells, as well as the subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: (same/less than)1ug/10e6 cells in 100ul or 100ul whole blood Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2387-10E
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by affinity chromatography.
References: 1. Hogg, N., et al. 1984. Eur. J. Immunol. 14:236. 2. Zabeleta, J., et al. 1998. Clin Diag. Lab. Immunol. 5:690. 3. Pascual, M., et. al. 1994. Eur. J. Immunol. 24:702. 4. Zola, Heddy, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules: The CD markers. WILEY-LISS. 5. Klickstein, LB., et al. 1988. J. Exp. Med. 168:1699.
Additional info: Recognizes human CD35.

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