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CD38 (ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, cADPr Hydrolase 1, T10)

CD38 (ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, cADPr Hydrolase 1, T10)

Cat no: C2390-01S

Supplier: United States Biological
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CD38 is a 42kD glycoprotein, also known as T10. It is an ADPribosyl hydrolase, expressed on B cells, NK cells, subset of T cells, brain, muscle, and kidney. In the mouse, CD38 expression is downregulated on mouse germinal center B cells and plasma cells, whereas this is not the case for humans. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, as well as adhesion and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2390-01S
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Oliver, A.M., et al., 1997. J. Immunol. 158:1108. 2. Howard, M., et al., 1993. Science 262:1056.
Additional info: Recognizes mouse CD38.

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