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CD38 (ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, cADPr Hydrolase 1, T10)

CD38 (ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, cADPr Hydrolase 1, T10)

Cat no: C2390-05T

Supplier: United States Biological
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CD38 is a 45 kD type II transmembrane glycoprotein, also known as T10. It is an ADP-ribosyl hydrolase, expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, as well as adhesion and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2390-05T
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Kishimoto, T., et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing, Inc. London. 2. Dieu, M. 1998. J. Exp. Med. 188:373. 3. Esser, M. et al. 2001. J. Virol. 75:6173. 4. Jeannin, P. et al. 1999. J. Immunol. 162:2044. 5. Kapsogeorgou, E. K. et al. 2001. J. Immunol. 166:3107. 6. van der Voort, R., et al. 1997. J. Exp. Med. 185:2121. 7. Bende, R.J., et al. 2003. Am. J. Pathol. 162:105. 8. Lehner, M., et al. 2008. J leukoc Biol. 83:883. 9. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 9. Ferrero, E., et al. 1999. J. Leukoc. Biol. 65:151. 10. Lund, F., et al. 1995. Immunol. Today 16:469.
Additional info: Recognizes human CD38. Species Crossreactivity: chimpanzee.

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