CD39, also known as Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) or Ecto-ATP diphosphohydrolase. CD39 was first described as a B cell activation marker, but is also expressed on natural killer cells, monocytes, dendritic cells and subsets of activated T cells. It is critical in the regulation of leukocyte accumulation within hypoxic tissues and plays a role in the thromboregulation of platelet and endothelial function activation. CD39, along with CD73, distinguishes regulatory T cells from other resting or activated T cells and plays a role in the suppressive action of regulatory T cells.
Applications:
Suitable for use in Flow cytometry. Other applications have not been tested.
Recommended Dilutions:
Flow cytometry: 1:25-1:200. Use 10ul to label 1x10e6 cells in 100ul.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.