CD39, also known as Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) or Ecto-ATP diphosphohydrolase. CD39 was first described as a B cell activation marker, but is also expressed on natural killer cells, monocytes, dendritic cells and subsets of activated T cells. It is critical in the regulation of leukocyte accumulation within hypoxic tissues and plays a role in the thromboregulation of platelet and endothelial function activation. CD39, along with CD73, distinguishes regulatory T cells from other resting or activated T cells and plays a role in the suppressive action of regulatory T cells.
Applications:
Suitable for use in Flow Cytometry. Other applications have not been tested.
Recommended Dilutions:
Flow cytometry: Neat. Use 10ul of the suggested working dilution to label 10e6 cells in 100ul. The Fc region may bind non-specifically to cells expressing low affinity Fc receptors
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.