Home  >  Products  >  CD4 (CD4 Antigen, CD4 Molecule, L3T4, Ly-4, T-cell Surface Glycoprotein CD4, T-cell Differentiation Antigen L3T4, T-cell Surface Antigen T4/Leu-3)
CD4 (CD4 Antigen, CD4 Molecule, L3T4, Ly-4, T-cell Surface Glycoprotein CD4, T-cell Differentiation Antigen L3T4, T-cell Surface Antigen T4/Leu-3)

CD4 (CD4 Antigen, CD4 Molecule, L3T4, Ly-4, T-cell Surface Glycoprotein CD4, T-cell Differentiation Antigen L3T4, T-cell Surface Antigen T4/Leu-3)

Cat no: C2255-31N

Supplier: United States Biological
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CD4 is a 55kD protein, also known as L3T4 or T4. It is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosin kinase, lck. This antibody is able to block CD4 mediated cell adhesion and T cell activation. It is also useful for in vivo and in vitro depletion of CD4+ T cells. This antibody blocks binding of the anti-mouse CD4 monoclonal antibodies C2255-31K and C2255-31L, but not C2255-31M antibody. This monoclonal antibody inhibits various responses of T helper cells to antigenic or mitogenic stimuli. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.25ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2255-31N
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry
Size: 500ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Bierer BE, et al. 1989. Annu. Rev. Immunol. 7:579. 3. Janeway CA. 1992. Annu. Rev. Immunol. 10:645.
Additional info: Recognizes mouse CD4.

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