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CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3) (Biotin)

CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3) (Biotin)

Cat no: C2255-06T

Supplier: United States Biological
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CD4, also known as T4, is a 55kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16. C2255-06T binds to the D1 domain of CD4 (CDR1 and CDR3 epitopes) and can block HIV gp120 binding and inhibit syncytia formation. Applications: Suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: Acetone-fixed, frozen Flow Cytometry: (same/less than)1ug /10e6 cells in 100ul volume. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2255-06T
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Conjugates: Biotin
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Labeled with Biotin.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al., 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Moir, S., et al., 1999. J. Virol. 73:7972. 3. Deng, M. C., et al., 1995. Circulation 91:1647. 4. Friedman, T., et al., 1999. J. Immunol. 162:5256. 5. Mack, C.L., et al. 2004. Pediatr. Res. 56:79.
Additional info: Recognizes human CD4.

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