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CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3)

CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3)

Cat no: C2255-05Q

Supplier: United States Biological
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CD4, also known as T4, is a 55kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16. This antibody binds to the D3 domain of CD4 and does not block HIV binding. Applications: Suitable for use in Flow Cytometry, Blocking and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e5 cells in 100ul Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2255-05Q
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Reinherz EL., et al. 1979. Proc. Natl. Acad. Sci. 76:4061. 3. Kmieciak, M., et al. 2009. J. Transl. Med. 7:89. (FC) 4. Cicin-Sain, L., et al. 2010. J. Immunol. 184:6739. 5. Rosenzweig, M., et al. 2001. J. Med. Primatol. 30:36. 6. Center, D., et al. 1996. Immunol. Today 17:476. 7. Gaubin, M., et al. 1996. Eur. J. Clin. Chem. Clin. Biochem. 34:723.
Additional info: Recognizes human CD4. Species Crossreactivity: chimpanzee, cynomolgus, rhesus.

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