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CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3)

CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3)

Cat no: C2255-06K

Supplier: United States Biological
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CD4, also known as T4, is a 55kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16. This antibody binds to the D1 domain of CD4 (CDR1 and CDR3 epitopes) and can block HIV gp120 binding and inhibit syncytia formation. Applications: Suitable for use in Flow Cytometry, Blocking and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e5 cells in 100ul Immunohistochemistry: Acetone-fixed, frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2255-06K
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Moir, S., et al. 1999. J. Virol. 73:7972. 3. Deng, M. C., et al. 1995. Circulation 91:1647. 4. Friedman, T., et al. 1999. J. Immunol. 162:5256. 5. Mack, C.L., et al. 2004. Pediatr. Res. 56:79. 6. Lan, R.Y., et al. 2006. Hepatology 43:729. 7. Zenaro, E., et al. 2009. J. Leukoc Biol. 86:1393. 8. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC). 9. Center, D., et al. 1996. Immunol. Today 17:476. 10. Gaubin, M., et al. 1996. Eur. J. Clin. Chem. Clin. Biochem. 34:723.
Additional info: Recognizes human CD4. Species Crossreactivity: chimpanzee.

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