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CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3)

CD4 (T-cell Surface Glycoprotein CD4, T-cell Surface Antigen T4/Leu-3)

Cat no: C2255-10A

Supplier: United States Biological
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CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. CD4 is a member of the immunoglobulin superfamily. It acts as the co-receptor for the T cell receptor (TCR) on T cells and amplifies the signal generated by TCR by recruiting the tyrosine kinase lck that is essential for activating many molecules involved in the signaling cascade of an activated T cell. It is an important component of the immune system and is also the cellular receptor for HIV-1. The protein consists of a cytoplasmic tail, one transmembrane region, and four extracellular domains, D1-D4. The gene encoding the protein CD4 maps to 12pter-p12 region of human chromosome. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:15-1:30 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2255-10A
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Arthos et al. Cell 54: 65, 1988. 2. Dalgleish et al. Nature 312: 763, 1984. 3. Gay et al. Nature 328: 626, 1987. 4. Stein et al. Adv Cancer Res 42: 67, 1984. 5. Sharma et al. Biochemistry 44: 16192, 2005.
Additional info: Recognizes human CD4.

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