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CD40 (B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CDW40, MGC9013, p50, TNFRSF5, Tumor necrosis factor receptor superfamily member 5)

CD40 (B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CDW40, MGC9013, p50, TNFRSF5, Tumor necrosis factor receptor superfamily member 5)

Cat no: C2392-05J

Supplier: United States Biological
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Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells. CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 Ligand) is essential for isotype switching (1). The CD40-CD154 interaction appears to have a role in artherosclerosis and cardiovascular disorders (3,4,5). Applications: Suitable for use in ELISA, Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 5x10e5 cultured Raji cells per tube were incubated 45 min on ice with 80ul of anti-CD40 antibody at 10ug/ml. Cells were washed twice and incubated with Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.36 log10 fluorescent units when compared to a Mouse1.2 IgG1 negative control at a similar concentration. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2392-05J
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride. No preservative added.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. C.L. Law, B. Wormann & T.W. LeBien, (1990) Leukemia 4:732-738, 2. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 90-91, 3. T.A. Foy, et al, (1996) Annu Rev Immunol 14:591-617, 4. M.R. Kuhn
Additional info: Recognizes human CD40. Binding of cross linked CD40 will partially activate B cells.

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