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CD40 (Biotin)

Cat no: C2392-05B


Supplier: United States Biological
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Application(s): Flow Cytometry Functional Application (activates B and NK cells in vivo and in vitro) USE/STABILITY: For long term storage keep unconjugated antibody at -20 degrees C. Avoid freeze/thaw cycles. Keep Biotin-conjugated formats at +4 degrees C. Do not freeze. Protect from light. Widely used stimulatory MAb to CD40 [1,2]. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects [3]. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes [4].
Catalogue number: C2392-05B
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Conjugates: Biotin
Size: 50ug
Form: Supplied as a liquid in sterile PBS.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity 5, 319 (1996) 2. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol. 28, 3738 (1998) 3. Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol. 166, 89 (2001) 4. Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med. 6, 673 (2000)
Additional info: Recognizes mouse CD40

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