Home  >  Products  >  CD40 (CD40 Antigen, CD40 Molecule, CDw40, CD40L Receptor, B-cell Surface Antigen CD40, Bp50, MGC9013, p50, Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5) (Low Endotoxin)
CD40 (CD40 Antigen, CD40 Molecule, CDw40, CD40L Receptor, B-cell Surface Antigen CD40, Bp50, MGC9013, p50, Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5) (Low Endotoxin)

CD40 (CD40 Antigen, CD40 Molecule, CDw40, CD40L Receptor, B-cell Surface Antigen CD40, Bp50, MGC9013, p50, Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5) (Low Endotoxin)

Cat no: C2392-03R

Supplier: United States Biological
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CD40 cell surface antigen is a 48kD glycoprotein expressed by B lymphocytes and weakly by some monocytes. CD40 is involved in the process of B cell selection in germinal centres and is vital in T cell-B cell interactions. Applications: Suitable for use in Flow cytometry, Immunoprecipitation and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry: paraffin and frozen sections. Requires protein digestion pre-treatment of paraffin embedded sections prior to staining eg. pronase or trypsin. Flow cytometry: 1:100- 1:200. Use 10ul to label 10e6 cells in 100ul. Optimal dilutions to be determined by the researcher. Hybridoma: NS1 myeloma cells with spleen cells from Balb/c mice. Immunohistochemistry Positive Control: Human tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2392-03R
Reactivities: Human, Canine
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 500ug
Form: Supplied as a liquid in Tris buffered saline.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatograpy. Endotoxin: (same/less than)0.01EU/ug
Alternative names: CD40 Molecule, TNF Receptor Superfamily Member 5
References: 1. . Quadbeck, B. et al. (2002) Maturation of thyroidal dendritic cells in Graves Disease. Scand. J. Immunol. 55: 612-620. 2. Kirsch, B. M. et al . (2005) The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function. Arthritis Res. Ther. 7: R694-R703. 3. Cheadle, E. et al. (2003) Mycobacterium bovis bacillus Calmette-Guerin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism. Immunology.108: 79-88. 4. Carpenter, E.L. et al. (2009) Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation. J Transl Med. 7: 93. 5. Garcia-Nieto, S. et al. (2010) Laminin and Fibronectin Treatment Leads to Generation of Dendritic Cells with Superior Endocytic Capacity. PLoS ONE. 5: 1-10. 6. Wang, Y.S. et al. (2007) Characterization of canine monocyte-derived dendritic cells with phenotypic and functional differentiation. Can J Vet Res. 71: 165-74.
Additional info: Recognizes human CD40. Species crossreactivity: canine.

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