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CD40 Ligand, soluble, Recombinant, Mouse (Cd40l, CD40-L, Cd40lg, sCD40L, CD154, HIGM1, IGM, IMD3, Ly62, Ly-62, T-BAM, T-cell Antigen Gp39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, Tnfsf5)

Cat no: C2392-31A

CD40 Ligand, soluble, Recombinant, Mouse (Cd40l, CD40-L, Cd40lg, sCD40L, CD154, HIGM1, IGM, IMD3, Ly62, Ly-62, T-BAM, T-cell Antigen Gp39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, Tnfsf5)

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2. \n\nBiological Activity: \nRecombinant sCD40L is fully biologically active when compared to standard. The ED50 is typically 5-10ng/ml as determined by the dose-dependent production of IL-8 by human PBMC

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SPECIFICATIONS

Catalog Number

C2392-31A

Size

5ug

Form

Supplied as a lyophilized powder from 10mM sodium phosphate, pH 7.5. Reconstitute with sterile ddH2O, 0.1% HSA or BSA to a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions.

Purity

(same/more than) 98% as determined by RP-HPLC; Reducing and non-reducing SDS-PAGE.

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