CD40 is a glycoprotein important for T-B lymphocytes interactions. The ligand for CD40 is CD154 (CD40L). The function of CD40 is involved in growth, differentiation, and isotype-switching on B cells and also involved to rescue B cells from apoptosis. CD40 is a 48 KD type I single chain trans- membrane glycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiated plasma cells. CD40 antigen is also present on Hodgkin's and Reed-Sternberg cells, follicular dendritic cells, some macrophages, basal epithelial cells and endothelial cells.
Applications:
Suitable for use in Flow Cytometry and ELISA. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.