Home  >  Products  >  CD40 (TNF receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CDW40, MGC9013, p50, TNFRSF5, Tumor necrosis factor receptor superfamily member 5 precursor)

CD40 (TNF receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CDW40, MGC9013, p50, TNFRSF5, Tumor necrosis factor receptor superfamily member 5 precursor)

Cat no: C2392-17H


Supplier: United States Biological
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CD40 is a glycoprotein important for T-B lymphocytes interactions. The ligand for CD40 is CD154 (CD40L). The function of CD40 is involved in growth, differentiation, and isotype-switching on B cells and also involved to rescue B cells from apoptosis. CD40 is a 48 KD type I single chain trans- membrane glycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiated plasma cells. CD40 antigen is also present on Hodgkin's and Reed-Sternberg cells, follicular dendritic cells, some macrophages, basal epithelial cells and endothelial cells. Applications: Suitable for use in Flow Cytometry and ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2392-17H
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: Foy, T.M. et. al. (1996) Annu. Rev. Immunol. 14,591 " 617; Eliopoulos, A.G. & Young, L.S. (2004) Curr. Opin. Pharmacol. 4,360 " 367; Werneburg, B. et. al. (2001) J. Biol. Chem. 276,43334 " 43342.
Additional info: Recognizes human CD40

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