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CD40 (Tumor Necrosis Factor Receptor Superfamily Member 5, B-cell Surface Antigen CD40, Bp50, CD40L Receptor, CDw40, TNFRSF5)

CD40 (Tumor Necrosis Factor Receptor Superfamily Member 5, B-cell Surface Antigen CD40, Bp50, CD40L Receptor, CDw40, TNFRSF5)

Cat no: C2392-02X

Supplier: United States Biological
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CD40 is a 48kD type I transmembrane glycoprotein, also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. C2392-02X has been reported to stimulate dendritic and B cell proliferation and block CD40- CD40L interactions. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2392-02X
Reactivities: Mouse
Applications: Flow Cytometry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgM
Purity: Purified by immunoaffinity chromatography.
References: 1. Kawano, T., et al., 1997. Science 278:1626. 2. Kaneko, Y., et al., 1996. Eur. J. Immunol. 26:3061. 3. Kashiwada, M., et al., 1996. Eur. J. Immunol. 26:1451. 4. Inaba, M., et al., 1995. Eur. J. Immunol. 25:1244. 5. Akiba, H., et al., 1999. J. Immunol. 162:7058. 6. Ridge, J.P., et al., 1998. Nature 393:474. 7. Morelli, A.E., et al., 2000. Transplantation 69:2647. 8. Ma, X-T., et al., 2006. Cancer Research 66:1169. 9. Yu, X., et al., 2006. J. Biol. Chem. 281: 15505.
Additional info: Recognizes mouse CD40.

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