Home  >  Products  >  CD40 (Tumor Necrosis Factor Receptor Superfamily Member 5, B-cell Surface Antigen CD40, Bp50, CD40L Receptor, TNFRSF5, AI326936, GP39, HIGM1, IGM, IMD3, p50, T-BAM, TRAP)
CD40 (Tumor Necrosis Factor Receptor Superfamily Member 5, B-cell Surface Antigen CD40, Bp50, CD40L Receptor, TNFRSF5, AI326936, GP39, HIGM1, IGM, IMD3, p50, T-BAM, TRAP)

CD40 (Tumor Necrosis Factor Receptor Superfamily Member 5, B-cell Surface Antigen CD40, Bp50, CD40L Receptor, TNFRSF5, AI326936, GP39, HIGM1, IGM, IMD3, p50, T-BAM, TRAP)

Cat no: C2392-05C

Supplier: United States Biological
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CD40 is a 48kD type I transmembrane glycoprotein, also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39) expressed on activated T cells, is important in costimulation and immune regulation. This antibody has been reported to stimulate dendritic and B cell proliferation and block CD40-CD40L interactions. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)1ug/10e6 cells in 100ul volume Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2392-05C
Reactivities: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgM
Purity: Purified
References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Bancherou J, et al. 1994. Annu. Rev. Immunol. 12:881. 3. Clark EA, et al. 1996. P. Natl. Acad. Sci. USA 83:4494.
Additional info: Recognizes mouse CD40.

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