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CD41 (Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet Membrane Glycoprotein IIb, ITGA2B, GP2B, ITGAB)

CD41 (Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet Membrane Glycoprotein IIb, ITGA2B, GP2B, ITGAB)

Cat no: C2394-45E

Supplier: United States Biological
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CD41 is a 125/25 kD alpha subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIba) and light chain (gpIIbB) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow cytometry: (same/less than)2ug/million cells in 100ul volume. Immunohistochemistry: aceton fixed frozen sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2394-45E
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by affinity chromatography.
References: 1. Knapp, W., et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. McCarty, O. J. T., et al. 2000. Blood 96:1789. 3. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 4. Denzin, L., et al. 1996. J. Exp. Med. 184:2153. 5. Denzin, L., et al. 1995. Cell 82:155. 6. Riberdy, J., et al. 1994. J. Cell Biol. 125:1225.
Additional info: Recognizes human CD41. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, capuchin monkey. Has been reported to block the activation of platelets by various stimuli, including collagen, and ADP.

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