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CD41a

Cat no: C2394-15L


Supplier: United States Biological
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The CD41 molecule is the integrin alphaIIb also known as platelet GPIIb. CD41 non-covalently associates with betaIII integrin (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. This antibody blocks platelet aggregation. CD41 completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes. The GPIIb/IIIa may be absent or strongly reduced in Glanzmann
Catalogue number: C2394-15L
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH7.4, 15mM sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Chen Z., Bao ZX., Yu AX., et al., 1987. A group monoclonal antibodies against human platelets with different functions. Chinese Science Bulletin. 24:1902. 2. Bao CX., Chen Z., Jin XQ., et al., 1987. HIP2: A new monoclonal antibody with stimulation for human platelet. Chinese J. of Hematology. 8(2):65. 3. Wu XW., Chen Z., Bao CX., et al., 1989. Production and application of anti-human platelet GPIIb/IIIa monoclonal antibodies. National Medical J. of China. 69(8):427. 4. Knapp, W., B. Dorken and E.P. Rieber, et al., eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York. 5. Bao CX., Liu JW., Chen GZ., et al., 1992. Some biological characterization of monoclonal antibody HIP2 receptor on platelet membrane glycoprotein IIB. Chinese J. of Hematology.13(2):66. 6. Schlossman, S., L. Boumsell, W. Gilks, et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press, New York. 7. Tadamitsu K, K.Hitoshi, A.E.G.Kr.van dem Borne, et al., eds. 1997. Leucocyte Typing Ⅵ: White Cell Differentiation Antigens. Garland Publishing, Inc., New York.
Additional info: Recognizes human CD41 molecule.

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