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CD43 (T Cell Marker, Leukosialin, Sialophorin, or Leukocyte Sialoglycoprotein, Galactoglycoprotein, GALGP, SPN)

CD43 (T Cell Marker, Leukosialin, Sialophorin, or Leukocyte Sialoglycoprotein, Galactoglycoprotein, GALGP, SPN)

Cat no: C2397-25F

Supplier: United States Biological
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CD43, a 135kD Type I transmembrane sialoglycoprotein, abundantly expressed on the surface of T-lymphocytes and hematopoietic cells. It is a member of sialomucin family and contains a heavily O-glycosylated extracellular domain, a transmembrane domain and an intracellular cytoplasmic domain. It exists in 2 isoforms; an 115kD form expressed on most T-cells and a 135kD form expressed in resting CD8+ cells. Natural ligands of CD43 are ICAM-1, Galectin-1 and MHC-1 suggesting a complex role of this protein in Leukocyte adhesion mediated by integrins, T-cell activation signaling cascade, anti-apoptotic and pro-apoptotic signaling and anti-adhesive properties based on interaction of each isoform with its ligand. Pathological role of CD43 is indicated in Wiskott-Aldrich syndrome. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution:: Immunohistochemistry (formalin fixed paraffin embedded): 1:50-1:100 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2397-25F
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Stross et al. J Clin Pathol 42: 953, 1989. 2. Borche et al. Eur J Immunol 17: 1523, 1987. 3. Mattioli et.al Blood, 104 (10); 3302-3304 (15 November 2004) 4. Gustavo et.al J Biol Chem, 273 (23); 14218-14224 (June 5, 1998) 5. Santana et.al J. Biol. Chem., 275 (40); 31460-31468 (October 6, 2000) 6. Mattioli et.al Blood, 104 (10); 3302-3304 (15 November 2004).
Additional info: Recognizes human CD43.

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