Home  >  Products  >  CD45 (CD45 Antigen, Leukocyte Common Antigen, LCA, L-CA, Protein Tyrosine Phosphatase Receptor Type C, PTPRC, Receptor-type Tyrosine-protein Phosphatase C, RT7, T200)
CD45 (CD45 Antigen, Leukocyte Common Antigen, LCA, L-CA, Protein Tyrosine Phosphatase Receptor Type C, PTPRC, Receptor-type Tyrosine-protein Phosphatase C, RT7, T200)

CD45 (CD45 Antigen, Leukocyte Common Antigen, LCA, L-CA, Protein Tyrosine Phosphatase Receptor Type C, PTPRC, Receptor-type Tyrosine-protein Phosphatase C, RT7, T200)

Cat no: C2400-21C

Supplier: United States Biological
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CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180kD) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Able to modulate the lysis of target cells by NK cells. Other applications not tested. Recommended Dilution: Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2400-21C
Reactivities: Rat
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
Alternative names: EC=3.1.3.48
References: 1. Giezeman-Smits KM, Gorter A, Van Vlierberghe RL, Eendenburg JD, Eggermont AM, Fleuren GJ, Kuppen PJ (1999) The regulatory role of CD45 on rat NK cells in target cell lysis. J Immunol 163: 71-76.
Additional info: Recognizes a common epitope of rat CD45, present on all rat leukocytes.

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