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CD45 (Leukocyte Common Antigen, LCA, Ly-5 T200)

CD45 (Leukocyte Common Antigen, LCA, Ly-5 T200)

Cat no: C2399-01B

Supplier: United States Biological
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CD45 belongs to a family of heavily glycosylated, high molecular weight transmembrane glycoproteins expressed on all cells of haematopoietic origin. Structurally heterogeneous, CD45 consists of a family of eight isoforms ranging from 180,000 to 220,000 MW generated by alternative splicing of three exons differentially expressed on subpopulation of lymphocytes. CD45 protein tyrosine phosphatase activity plays a central role in T-cell activation. CD45 plays an important role in signal transduction inhibition or upregulation of various immunological functions, Hybridoma: Mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CD45 protein. Applications: Suitable for use in ELISA, Western Blotting. Other applications not tested. Recommended Dilution: Western Blotting: 1:1000-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2399-01B
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 50ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by Protein G affinity chromatography.
References: Evgueni K , et al., (2005) Immunogenetics 57(5):374-383 Nick H , et al., (2005) Immunology 117(2):145-155 Francois S , et al., (2004) Immunology 113(4):441-452 Tara S , et al., (2003) Proc Natl Acad Sci U S A 100(10):5997-6002
Additional info: Recognizes human CD45.

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