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CD45 (Receptor-type Tyrosine-protein Phosphatase C, Leukocyte Common Antigen, L-CA, T200, PTPRC)

CD45 (Receptor-type Tyrosine-protein Phosphatase C, Leukocyte Common Antigen, L-CA, T200, PTPRC)

Cat no: C2400-10M

Supplier: United States Biological
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CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA), B220, and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2400-10M
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Kishihara, K., et al. 1993. Cell 74:143. 3. Esser, M., et al. 2001. J. Virol. 75:6173. (WB) 4. Yamada, T., et al. 2002. J. Biol. Chem. 277:28830. 5. Nagano, M., et al. 2007. Blood 110:151. 6. Jiang Q., et al. 2008. Blood 112:2858. 7. Nagano, M., et al. 2007. Blood 110:151. 8. Morozov, A., et al. 2010. Clin Cancer Res. 16:5630. 9. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 10. Thomas, M. 1989. Annu. Rev. Immunol. 7:339. 11. Trowbridge, I., et al. 1994. Annu. Rev. Immunol.12:85.
Additional info: Recognizes human CD45. Species Crossreactivity: chimpanzee.

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