CD45, Recombinant, Human (Leukocyte Common Antigen, LCA, LY-5 T200)

CD45 (1102-1150 a.a.) leukocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kD) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals.\n\nApplications: \nSuitable for use in ELISA, Western Blot and Inhibition assays. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C2399-01R

Size

2ug

Form

Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol.

Purity

On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 33kD

References

1. CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells.\n\nInt J Mol Med 2006 Aug;18(2):233-40\n\n2. Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.\n\nNat Immunol 2006 Jul 2;\n\n3. CD45 monoclo nal antibody-mediated cytolysis of human NK and T lymphoma cells.\n\nHaematologica 2006 Jul;91(7):886-94\n\n4. CD45 monoclonal antibody mediated cytolysis of human NK and T lymphoma cells.\n\nHaematologica 2006 Jul;91(7):866A\n\n5. MAb V58 Anti-Type XVII Collagen; MAb Against Carp Sperm Creatine Kinase; MAb to FABP4; MAb Against Daintain; MAb Human CacyBP; MAb Against Canine CD45 Homologue; MAb 1B6, 2A11, 6A12, 7E11, and 8A12 Anti-Human Nup62; MAb 1B3, 3B3, HAb18Gedomab1, and HAb18Gedomab2; MAb PHR1 Anti-GARFT; MAb JY/93 Anti-Murine CD72.\n\nHybridoma (Larchmt) 2006 Jun;25(3):168-78\n\n6. MAb V58 Anti-Type XVII Collagen; MAb Against Carp Sperm Creatine Kinase; MAb to FABP4; MAb Against Daintain; MAb Human CacyBP; MAb Against Canine CD45 Homologue; MAb 1B6, 2A11, 6A12, 7E11, and 8A12 Anti-Human Nup62; MAb 1B3, 3B3, HAb18Gedomab1, and HAb18Gedomab2; MAb PHR1 Anti-GARFT; MAb JY/93 Anti-Murine CD72.\n\nHybridoma (Larchmt) 2006 Jun;25(3):163-78