CD45R (B220)

Cat no: C2400-28K

Supplier: United States Biological

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CD45R is an isoform of CD45, also known as B220. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C2400-28K
Reactivities:	Human, Mouse, Feline
Hosts:	Rat
Applications:	Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size:	500ug
Form:	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type:	Mab
Isotype:	IgG2a,k
Purity:	Purified by immunoaffinity chromatography.
References:	1. Coffman, R.L. 1982. Immunol. Rev. 69:5. 2. George, A., et al. 1994. J. Immunol. 152:1014. 3. Asensi, V., et al. 1989. Immunology 68:204. 4. Domiati-Saad, R., et al. 1993. J. Immunol. 151:5936. 5. Hata, H., et al. 2004. J. Clin. Invest. 114:582. 6. Monteith, C. E. et al. 1996. Can. J. Vet.Res. 60:193. 7. Shih, F. F., et al. 2006. J. Immunol. 176:3438. 8. Chang, C. L-T., et al. 2007. J. Immunol. 178:6984. 9. Fazilleau, N., et al. 2007. Nature Immunol. 8:753. 10. Lang, GL., et al. 2008. Blood 111:2158. 11. Charles, N., et al. 2010. Nat. Med. 16:701. (FC) 12. Barclay, A., et al. 1997. The Leukocyte Antigen FactsBook, Academic Press. 13. Trowbridge, I.S., et al. 1993. Annu. Rev. Immunol. 12:85. 14. Kishihara, K., et al. 1993. Cell 74:143. 15. Pulido, R., et al. 1988. J. Immunol. 140:3851.
Additional info:	Recognizes mouse CD45R. Species Crossreactivity: human, feline.

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CD45R (B220)

Cat no: C2400-28K

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