Home  >  Products  >  CD45RA (CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C Polypeptide, PTPRC, T200, T200 Glycoprotein)
CD45RA (CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C Polypeptide, PTPRC, T200, T200 Glycoprotein)

CD45RA (CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C Polypeptide, PTPRC, T200, T200 Glycoprotein)

Cat no: C2400-30L

Supplier: United States Biological
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CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naive T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2400-30L
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Yamada, T., et al. 2002. J. Biol. Chem. 277:28830. (WB, Block) 3. Weninger, W., et al. 2003 J Immunol. 170:4638. (IHC) 4. Imanguli, M.M., et al. 2009. Blood. 113:3620 (IHC) 5. Roque, S., et al. 2007. J Immunol.178:8028. (FC) 6. Smeltz, R.B., 2007. J. Immunol. 178:4786. (FC) 7. Palendira, U., et al. 2008. Blood. (FC) 8. Kuttruff, S., et al. 2009. Blood. 113:358. (FC) 10. Thakral, D., et al. 2008. J. Immunol. 180:7431. (FC) 11. Alanio, C., et al. 2010. Blood. 115:3718. (FC) 12. Iannello, A., et al. 2010. J. Immunol. 184:114. (FC) 13. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 14. Thomas, M. 1989. Annu. Rev. Immunol. 7:339. 15. Trowbridge, I., et al. 1994. Annu. Rev. Immunol.12:85.
Additional info: Recognizes human CD45RA. Species Crossreactivity: chimpanzee.

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