Home  >  Products  >  CD45RA (CD45R, CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C Polypeptide, PTPRC, T200, T200 Glycoprotein)
CD45RA (CD45R, CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C Polypeptide, PTPRC, T200, T200 Glycoprotein)

CD45RA (CD45R, CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C Polypeptide, PTPRC, T200, T200 Glycoprotein)

Cat no: C2400-42J

Supplier: United States Biological
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Leukocyte common antigen is expressed exclusively on the surface of hematolymphoid cells and their progenitors, including T and B lymphocytes, granulocytes, monocytes, and macrophages. Mature erythrocytes and megakaryocytes do not express CD45. The CD45 antibody is an important component of the antibody panel used to distinguish hematolymphoid neoplasms from non-hematolymphoid neoplasms, including undifferentiated or anaplastic large cell tumors (malignant lymphoma, melanoma, and carcinoma). In a study of nasophryngeal biopsies, LCA staining was positive for all malignant melanomas and negative for all nasopharyngeal carcinomas. LCA may be used together with cytokeratin antibodies to identify the cell-lineage of anaplastic tumors, demonstrating the ability to identify lymphoma and carcinoma in up to 88% of cases in a single study. Consists of a mixture of three monoclonal antibodies: CD45, CD45RA and CD45RB. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: Crossreaction occurs with an intracellular 60kD protein of unknown identity like other anti-CD45RA Mabs. Immunohistochemistry: No treatment of paraffin sections is necessary. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2400-42J
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by ammonium sulfate precipitation.
References: 1. Bazil, V., et al., 1989, Fol. Biol. 35, 289. 2. Bazil, V. et al., 1989 Immunogenetics 29, 202. 3. Leucocyte Typing IV, ed. W. Knapp et al. Oxford University Press, Oxford 1989, 4th Workshop, Nr. N907. 4. Leucocyte Typing V. Schlossman S. et al. (1995), Oxford University Press.
Additional info: Recognizes the 205-220kD form of CD45. Present on peripheral B-lymphocytes as well as on a subpopulation of the peripheral T-lymphocytes. The population of CD4+ T-lymphocytes carrying the CD45RA determinant is the non activated suppressor-inducer subset of CD4 T-lymphocytes.

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