Home  >  Products  >  CD45RA (protein tyrosine phosphatase, receptor type, C, B220, CD45, CD45R, GP180, LCA, L-CA, Leukocyte common antigen, LY5, T200)
CD45RA (protein tyrosine phosphatase, receptor type, C, B220, CD45, CD45R, GP180, LCA, L-CA, Leukocyte common antigen, LY5, T200)

CD45RA (protein tyrosine phosphatase, receptor type, C, B220, CD45, CD45R, GP180, LCA, L-CA, Leukocyte common antigen, LY5, T200)

Cat no: C2400-41E

Supplier: United States Biological
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CD45 is a receptor-tyrosine phosphatase required for antigen-induced signaling in T-cells and B-cells; its substrates are unknown. Interestingly, it associates with several Src-family tyrosine kinases, which are inhibited by tyrosine phosphorylation in their c-termini, suggesting a mechanism for signaling by CD45. Antigen distribution: B-cells (lg+) > 95% T-cells (E+) 70 + 10% Peripheral blood lymphocytes 68 + 8% T-cells (CD4+) 50 + 10% Monocytes 50 + 20% Thymocytes < 5% Granulocytes < 1% Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Optimal dilutions to be determined by the researcher. Positive Control: RAW264 Cell Lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2400-41E
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 10mM sodium azide, 1 mg/mL bovine serum albumin.
P type: Mab
Isotype: IgG2b
Purity: Purified
References: 1. Schlossman, S., et al. (1995). Leucocyte Typing V, Eds. Oxford University Press, Oxford. 383-385. 2. Bazil, V., et al. (1989). Fol. Biol. (Prague). 35:289-98. 3. Leucocyte Typing IV. (1989). Oxford University Press.
Additional info: This antibody recognizes the 220kD molecular weight component of the leucocyte common antigen complex expressed on some CD4+ T lymphocytes, B lymphocytes and CD8+ lymphocytes. The CD45R+/CD4+ lymphocytes functionally exert suppressor/inducer activity in in vitro assay systems. Species Crossreactivity: mouse. Species sequence homology: human and rat.

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