Home  >  Products  >  CD45RB (CD45R, CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C, PTPRC, Receptor-type Tyrosine-protein Phosphatase C Polypeptide, T200, T200 Glycoprotein)

CD45RB (CD45R, CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C, PTPRC, Receptor-type Tyrosine-protein Phosphatase C Polypeptide, T200, T200 Glycoprotein)

Cat no: C2400-47K


Supplier: United States Biological
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Leukocyte common antigen is expressed exclusively on the surface of hematolymphoid cells and their progenitors, including T and B lymphocytes, granulocytes, monocytes, and macrophages. Mature erythrocytes and megakaryocytes do not express CD45. The CD45 antibody is an important component of the antibody panel used to distinguish hematolymphoid neoplasms from non-hematolymphoid neoplasms, including undifferentiated or anaplastic large cell tumors (malignant lymphoma, melanoma, and carcinoma). In a study of nasophryngeal biopsies, LCA staining was positive for all malignant melanomas and negative for all nasopharyngeal carcinomas. LCA may be used together with cytokeratin antibodies to identify the cell-lineage of anaplastic tumors, demonstrating the ability to identify lymphoma and carcinoma in up to 88% of cases in a single study. Consists of a mixture of three monoclonal antibodies: CD45, CD45RA and CD45RB. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2400-47K
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH7.4, 15mM sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified (>95% SDS-PAGE)
Alternative names: EC=3.1.3.48
Additional info: Recognizes a protein determinant of CD45RB. Not neuraminidase sensitive. Reactivity can be blocked by a peptide including aa79-88.

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