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CD46 (Membrane cofactor protein, MCP)

CD46 (Membrane cofactor protein, MCP)

Cat no: C2401-02C

Supplier: United States Biological
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CD46, also designated membrane cofactor protein, is a 45-70kD protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). Applications: Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry (frozen), Immunoprecipitation and Western Blot. Also suitable for inhibition of biological activity. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10 Western Blot: 1:10 (non-reduced sample treatment and SDS-PAGE) Immunohistochemistry: 1:10 Immunoprecipitation: 25ug antibody and 25ug Protein G-Sepharose were used to immunoprecipitate 10e7 cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2401-02C
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: membrane cofactor protein, MCP
References: 1. Kurita-Taniguchi, M et al; Functional modulation of human macrophages through CD46 (Measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46. J Immunol 2000, 165: 5143 2. Hirano, A et al; Ligation of human CD46 with purified complement C3b or F(ab
Additional info: Recognizes the SCR2 domain of CD46.

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