Home  >  Products  >  CD49c (iIntegrin alpha-3, CD49 Antigen-like Family Member C, FRP-2, Galactoprotein B3, GAPB3, VLA-3 Subunit alpha, ITGA3, MSK18)
CD49c (iIntegrin alpha-3, CD49 Antigen-like Family Member C, FRP-2, Galactoprotein B3, GAPB3, VLA-3 Subunit alpha, ITGA3, MSK18)

CD49c (iIntegrin alpha-3, CD49 Antigen-like Family Member C, FRP-2, Galactoprotein B3, GAPB3, VLA-3 Subunit alpha, ITGA3, MSK18)

Cat no: C2404-08H

Supplier: United States Biological
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CD49c is a 150 kD a integrin chain known as a3 integrin or VLA-3 a chain. It is a type I transmembrane glycoprotein which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c forms a heterodimer with integrin b1 (a3b1, CD49c/CD29, VLA-3) and is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells and dermal fibroblasts. Weak expression has been reported on leukocytes. VLA-3 plays a role in cell-cell and cell-matrix adhesion through binding Kalinin, collagen, laminin-1, laminin-5, entactin, and fibronectin. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2404-08H
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Pattaramalai, S., et al. 1996. Exp. Cell. Res. 222:281. 2. Skubitz, A.P., et al. 1996. Am. J. Pathol. 148:1445. 3. Skubitz, A.P., et al. 1998. FEBS Lett. 426:386. 4. Zola, H., et al. 2007. Leukocyte and stromal Cell Molecules: the CD Markers. John Wiley & Sons, Inc.
Additional info: Recognizes human CD49c.

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