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CD49d (Integrin alpha-4, CD49 Antigen-like Family Member D, Integrin alpha-IV, VLA-4 Subunit alpha, ITGA4)

CD49d (Integrin alpha-4, CD49 Antigen-like Family Member D, Integrin alpha-IV, VLA-4 Subunit alpha, ITGA4)

Cat no: C2404-44G

Supplier: United States Biological
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CD49d is a 150 kD a integrin chain known as a4 integrin or VLA-4 a chain. It forms a heterodimer with either integrin b1 (a4b1, VLA-4) or b7 (a4b7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. a4b7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2404-44G
Reactivities: Human, Bovine, Canine, Feline, Sheep
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 2. Jeong, S-H., et al. 2004. J. Virol. 78:6995. (Costim) 3. Vogel, T. U., et al. 2002. J. Immunol. 169:4511. (Costim) 4. Kleinewietfeld, M., et al. 2009. Blood 113:827. (FC) 5. Palacious, F., et al. 2010. Blood 115:4488. 6. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 7. Sestak, K., et al. 2007. Vet. Immunol. Immunopathol. 119:21. 8. Elices, M., Ed.1995. Springer Semin. Immunopathol. 16(4). 9. Lobb, R., et al. 1994. J. Clin. Invest. 94:1722.
Additional info: Recognizes human CD49d. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, equine, bovine, sheep, canine, feline.

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