Home  >  Products  >  CD49e (CD49 Antigen-like Family Member E, Fibronectin Receptor alpha, FNRA, Integrin alpha-F, Integrin alpha 5, Integrin alpha-5, ITGA5, Very Late Activation Protein 5 alpha, VLA-5, VLA5A)
CD49e (CD49 Antigen-like Family Member E, Fibronectin Receptor alpha, FNRA, Integrin alpha-F, Integrin alpha 5, Integrin alpha-5, ITGA5, Very Late Activation Protein 5 alpha, VLA-5, VLA5A)

CD49e (CD49 Antigen-like Family Member E, Fibronectin Receptor alpha, FNRA, Integrin alpha-F, Integrin alpha 5, Integrin alpha-5, ITGA5, Very Late Activation Protein 5 alpha, VLA-5, VLA5A)

Cat no: C2405-02J

Supplier: United States Biological
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The monoclonal antibody is directed against the CD49e-antigen, molecular weights: 17, 130kD, (GP Ic or VLA-5 alpha-chain), which can form distinct complexes with either the CD29-antigen (GP IIa or VLA beta-chain), resulting in the VLA-5 (alpha-5, beta-1) complex which is expressed on human platelets. Platelet VLA-5 functions as a fibronectin receptor and platelet adhesion to fibronectin is inhibited by this antibody. Applications: Suitable for use in Indirect Immunofluorescence, Flow Cytometry and Fluorescent Microscopy. Other applications not tested. Recommended Dilution: Immunofluorescence: For studies on platelets, care should be taken to avoid activation of platelets during drawing of blood. Platelet activation markers are weakly expressed on platelets prepared from directly fixed normal blood. The expression is max. on thrombin (1U/ml) stimulated washed platelets. Fix cells or platelets with 1% paraformaldehyde, wash and adjust to ~108/ml for further incubations. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2405-02J
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunofluorescence
Size: 1ml
Form: Supplied as a liquid in 20mM TRIS, 150mM sodium chloride, pH 8.0,10mg BSA, 0.001% Merthiolate.
P type: Mab
Isotype: IgG2b
Purity: Purified by ammonium sulfate precipitation and Ion Exchange chromatography.
Alternative names: Fibronectin Receptor alpha Polypeptide, Fibronectin Receptor Subunit alpha
References: 1. te Velde, A., et al., 1988, J. of Immunology 140, 1548.
Additional info: Recognizes human CD49e. Reacts with platelets and monocytes. Reacts weakly with T-cells and granulocytes and with various cell types of non-hemopoietic origin.

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