Home  >  Products  >  CD49e (CD49 Antigen-like Family Member E, Fibronectin Receptor alpha, FNRA, Integrin alpha-F, Integrin alpha 5, Integrin alpha-5, ITGA5, Very Late Activation Protein 5 alpha, VLA-5, VLA5A)
CD49e (CD49 Antigen-like Family Member E, Fibronectin Receptor alpha, FNRA, Integrin alpha-F, Integrin alpha 5, Integrin alpha-5, ITGA5, Very Late Activation Protein 5 alpha, VLA-5, VLA5A)

CD49e (CD49 Antigen-like Family Member E, Fibronectin Receptor alpha, FNRA, Integrin alpha-F, Integrin alpha 5, Integrin alpha-5, ITGA5, Very Late Activation Protein 5 alpha, VLA-5, VLA5A)

Cat no: C2405-02L1

Supplier: United States Biological
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Integrin a5, is a 140-150kD integrin alpha chain that forms dimers with at least five beta chains including b1, 3, 5, 6, and 8. It is a 1018aa residue type I membrane protein with a large 962aa extracellular domain (ECD) and a short 32aa cytoplasmic tail. The N-terminal region of Integrin a5, which is important for ligand binding, contains seven FG-GAP (phenylalanyl-glycyl and glycyl-alanyl-prolyl) consensus repeats that fold into a b-propeller domain. Furin cleavage of the Integrin a5 ECD occurs after Gly 889, generating a disulfide-linked, heteromeric subunit Integrin a5 chain. Integrin a5-containing integrins bind multiple ECM molecules, including Vitronectin, Osteopontin, MMP-2, and TSP. The ECD of human Integrin 5 shares 92aa sequence identity with mouse Integrin a5 ECD. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2405-02L1
Reactivities: Human
Hosts: Mouse
Size: 100ug
Form: Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
P type: Mab
Isotype: IgG2A
Purity: Purified by Protein A/G affinity chromatography.
Additional info: Recognizes human Integrin a5. No cross-reactivity with recombinant mouse Integrin a5, recombinant human Integrin a1, 2, 3, 4, 6, 7x2, 8, 9, 10, 11, M, X, D, or Integrin b1.

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