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CD49e (Integrin alpha-4, CD49 Antigen-like Family Member D, Integrin alpha-IV, VLA-4 Subunit alpha, ITGA4)

CD49e (Integrin alpha-4, CD49 Antigen-like Family Member D, Integrin alpha-IV, VLA-4 Subunit alpha, ITGA4)

Cat no: C2405-02R

Supplier: United States Biological
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CD49e is a type I integral membrane glycoprotein, known as a5 integrin, VLA-5 a chain. It forms noncovalent heterodimer with integrin b1 (CD29). CD49e contains two disulfide-linked subunits of 135 kD and 24 kD, and is mainly expressed on thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, and some myeloid leukemia cells. CD49e/CD29 complex binds to fibronection and neural adhesion molecule L1. It mediates monocytes migration, involves in the regulation of cells survival and apoptosis, and co-stimulates T cell activation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2405-02R
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Frank, N.Y., et al. 2005. Cancer Res. 15:4320. 2. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 3.Tran Van Nhieu, GT. and RR. Isberg. 1991. J. Biol. Chem. 266:24367. 4. Isaji, T., et al. 2006.J. Biol. Chem. 281:33258.
Additional info: Recognizes human CD49e.

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