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CD49f (Integrin alpha-6, CD49 Antigen-like Family Member F, VLA-6, ITGA6)

CD49f (Integrin alpha-6, CD49 Antigen-like Family Member F, VLA-6, ITGA6)

Cat no: C2405-03P

Supplier: United States Biological
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CD49f is a 120 kD integrin family member, also known as VLA-6 a chain and a6 integrin subunit. CD49f associates with either integrin b1 (CD29) or integrin b4 (CD104) to form receptors (VLA-6 or a6b4 complex) for laminin and kalinin. CD49f is expressed on platelets, monocytes, T cells, placental trophoblasts, epithelial and endothelial cells. CD49f is involved in adhesion and can act as a co-stimulatory molecule for T cell activation and proliferation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2405-03P
Reactivities: Human, Mouse, Bovine, Canine, Feline, Porcine, Rabbit, Sheep
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Georas, S. N., et al. 1993. Blood 82:2872. 2. Honda, T., et al. 1995. J. Clin. Endocrinol. Metab. 80:2899. 3. Sonnenberg, A., et al. 1986. J. Histochem. Cytochem. 34:1037. 4. Nakamura, K., et al. 1997 Biochem. Biophys. Res. Commun. 235:524. 5. Sonnenberg, A., et al. 1987 J. Biol. Chem. 262:10376. 6. Deregibus, M.C.., et al. 2007. Blood. doi:10.1182/blood-2007-03-078709. 7. Horwitz, K.B., et al. 2008. Proc Natl Acad Sci U S A. 105:5774. 8. Nardella, C., et al. 2009. Sci Signal. 2:55. 9. Xu, T., et al. 2010. Mol Cancer Ther. 9:438. 10. Stepp, M.A., et al. 2007. J Cell Sci. 120:2851. 11. Jo, M., et al. 2010. Cancer Res. 70:8948. 12. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 13. Sonnenberg A., et al. 1990. J. Cell. Biol. 110:2145. 14. Sonnenberg, A., et al. 1990. J. Cell. Sci. 96:207. 15. Aumailly, M.R., et al. 1990. Exp. Cell Res. 188:55. 16. Niessen, C. M., et al. 1994. Exp. Cell Res. 211:360.
Additional info: Recognizes mouse CD49f. Species Crossreactivity: baboon, cynomolgus, rhesus, equine, bovine, sheep, porcine, canine, feline, rabbit, human.

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